diff --git a/tsdoc/src/configuration/TSDocConfiguration.ts b/tsdoc/src/configuration/TSDocConfiguration.ts
index 20e39a5f..a62352b5 100644
--- a/tsdoc/src/configuration/TSDocConfiguration.ts
+++ b/tsdoc/src/configuration/TSDocConfiguration.ts
@@ -18,6 +18,7 @@ export class TSDocConfiguration {
   private readonly _validation: TSDocValidationConfiguration;
   private readonly _docNodeManager: DocNodeManager;
   private readonly _supportedHtmlElements: Set<string>;
+  private readonly _linkUrlPrefixes: Set<string>;
 
   public constructor() {
     this._tagDefinitions = [];
@@ -26,6 +27,7 @@ export class TSDocConfiguration {
     this._validation = new TSDocValidationConfiguration();
     this._docNodeManager = new DocNodeManager();
     this._supportedHtmlElements = new Set();
+    this._linkUrlPrefixes = new Set();
 
     this.clear(false);
 
@@ -46,6 +48,7 @@ export class TSDocConfiguration {
     this._validation.reportUnsupportedTags = false;
     this._validation.reportUnsupportedHtmlElements = false;
     this._supportedHtmlElements.clear();
+    this._linkUrlPrefixes.clear();
 
     if (!noStandardTags) {
       // Define all the standard tags
@@ -89,6 +92,29 @@ export class TSDocConfiguration {
     return Array.from(this._supportedHtmlElements.values());
   }
 
+  /**
+   * URI-style prefixes that should be treated as URL destinations in `{@link ...}` tags.
+   */
+  public get linkUrlPrefixes(): string[] {
+    return Array.from(this._linkUrlPrefixes.values());
+  }
+
+  public addLinkUrlPrefix(prefix: string): void {
+    if (!/^[A-Za-z][A-Za-z0-9+.-]*$/.test(prefix)) {
+      throw new Error(`Invalid link URL prefix: "${prefix}"`);
+    }
+
+    this._linkUrlPrefixes.add(prefix.toLowerCase());
+  }
+
+  public clearLinkUrlPrefixes(): void {
+    this._linkUrlPrefixes.clear();
+  }
+
+  public isLinkUrlPrefixAllowed(prefix: string): boolean {
+    return this._linkUrlPrefixes.has(prefix.toLowerCase());
+  }
+
   /**
    * Register custom DocNode subclasses.
    */
diff --git a/tsdoc/src/parser/NodeParser.ts b/tsdoc/src/parser/NodeParser.ts
index 328553d3..c583a437 100644
--- a/tsdoc/src/parser/NodeParser.ts
+++ b/tsdoc/src/parser/NodeParser.ts
@@ -78,6 +78,20 @@ export class NodeParser {
     this._currentSection = parserContext.docComment.summarySection;
   }
 
+  private _isConfiguredLinkUrlDestination(linkDestination: string): boolean {
+    const colonIndex: number = linkDestination.indexOf(':');
+    if (colonIndex <= 0) {
+      return false;
+    }
+
+    if (linkDestination.indexOf('://') > 0) {
+      return false;
+    }
+
+    const prefix: string = linkDestination.substring(0, colonIndex);
+    return this._configuration.isLinkUrlPrefixAllowed(prefix);
+  }
+
   public parse(): void {
     const tokenReader: TokenReader = new TokenReader(this._parserContext);
 
diff --git a/tsdoc/src/parser/__tests__/NodeParserLinkTag.test.ts b/tsdoc/src/parser/__tests__/NodeParserLinkTag.test.ts
index e9b07c26..4b3cd710 100644
--- a/tsdoc/src/parser/__tests__/NodeParserLinkTag.test.ts
+++ b/tsdoc/src/parser/__tests__/NodeParserLinkTag.test.ts
@@ -1,6 +1,7 @@
 // Copyright (c) Microsoft Corporation. All rights reserved. Licensed under the MIT license.
 // See LICENSE in the project root for license information.
 
+import { TSDocConfiguration } from '../../configuration/TSDocConfiguration';
 import { TestHelpers } from './TestHelpers';
 
 test('00 Link text: positive examples', () => {
@@ -54,6 +55,22 @@ test('03 URL destination: negative examples', () => {
   );
 });
 
+test('03b URL destination: configured URI prefixes', () => {
+  const configuration: TSDocConfiguration = new TSDocConfiguration();
+  configuration.addLinkUrlPrefix('mailto');
+  configuration.addLinkUrlPrefix('xref');
+
+  TestHelpers.parseAndMatchNodeParserSnapshot(
+    [
+      '/**',
+      ' * {@link mailto:bob@example.com}',
+      ' * {@link xref:MyNamespace.MySymbol|link text}',
+      ' */'
+    ].join('\n'),
+    configuration
+  );
+});
+
 test('04 Declaration reference with package name: positive examples', () => {
   TestHelpers.parseAndMatchNodeParserSnapshot(
     [