SonoForge is an open, closed-loop DBTL platform for de novo design of biomolecules that let neurons talk to ultrasound — the basis of non-invasive molecular brain–computer interfaces. It designs gas-vesicle acoustic reporter genes via SE(3) flow-matching, molecular dynamics, and constrained Bayesian optimization, RL, and preference learning.
machine-learning molecular-dynamics computational-biology pytorch bayesian-optimization brain-computer-interface active-learning protein-design state-space-models jax de-novo-design gflownet flow-matching gas-vesicles acoustic-reporter-genes
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Updated
Jul 5, 2026 - Python